Widespread intronic polyadenylation diversifies immune cell transcriptomes

Widespread intronic polyadenylation diversifies immune cell transcriptomes

Widespread intronic polyadenylation diversifies immune cell transcriptomes, Published online: 30 April 2018; doi:10.1038/s41467-018-04112-z

Recognition of intronic polyadenylation (IpA) signals can lead to expression of truncated proteins lacking C terminal domains. Analysis of 3ʹ -seq and RNA-seq shows that IpA is widespread in circulating immune cells, while multiple myeloma cells show loss of IpA isoforms that are normally expressed in plasma cells, impacting key genes in the disease.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader https://ift.tt/2rahoGO