GSE107965 Transcriptome analysis of human embryonic stem cells (hESCs) and human fibroblasts upon rapamycin

Contributors : Atilgan Yilmaz ; Mordecai Peretz ; Nissim Benvenisty
Series Type : Expression profiling by high throughput sequencing
Organism : Homo sapiens

Rapamycin inhibits mTORC1 complex in a variety of cells. We demonstrated that hESCs are more sensitive to rapamycin treatment as compared to somatic cells (BJ Fibroblasts) and also certain cancer cells (KBM7 cells). To study the molecular mechanisms of this disparity, we performed a transcriptome analysis (RNAseq) of rapamycin-treated hESCs and human fibroblasts for two time points (2 and 4 days of treatment).

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