Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance

Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance

Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance, Published online: 30 April 2018; doi:10.1038/s41593-018-0144-y

Chronic morphine use can lead to tolerance and AC superactivation. This paper identifies a molecular mechanism by which V1bR signaling promotes this process, providing a potential approach to enhance morphine analgesia without increasing tolerance.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader https://ift.tt/2r9XlYg