Replacement of Sedentary Time with Physical Activity: Impact on Lipoproteins

Purpose Limited data on the relationship between physical activity and lipoprotein particle profiles exist. Our objective was to investigate associations between objectively measured physical activity and lipoprotein particle size and number, and specifically whether substituting daily sedentary behaviour with light activity or moderate to vigorous physical activity (MVPA), is associated with beneficial alterations to the lipoprotein profile among adults and those at increased cardiometabolic risk (obese and insulin resistant subjects). Methods Sedentary behaviour and physical activity intensity and duration were measured for 7-consecutive days using the GENEActiv accelerometer in a cross-sectional adult cohort (n=396, mean age 59.6±5.5 years). Lipoprotein particle size and subclass concentrations were determined using nuclear magnetic resonance (NMR) spectroscopy. Isotemporal substitution regression modelling quantified the associations between replacing 30 minutes per day of sedentary behaviour with equal amounts of light activity and MVPA on lipoprotein profiles. Results Daily duration of MVPA was inversely associated with large VLDL particles and lipoprotein insulin resistance scores (LP-IR) (P

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