Three recent media pieces on the unproven, for-profit stem cell clinic industry paint an unflattering picture of this industry. At the intersection of these pieces is the clinic "treatment" consisting of fat stem cells (being manufactured as in a screenshot [...]
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Amyloid-β — a reflection of risk or a preclinical marker?
Amyloid-β — a reflection of risk or a preclinical marker?, Published online: 30 April 2018; doi:10.1038/s41582-018-0008-9
In a recent study, individuals with brain amyloid-β accumulation but no cognitive impairment were classified as being at risk of Alzheimer disease, yet amyloid-β is widely considered to be a pathological biomarker of Alzheimer disease rather than a risk factor — it cannot be both.
British Journal of Surgery, EarlyView.
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People with a mental illness experience a higher morbidity and mortality from chronic diseases relative to the general population. A higher prevalence of risk behaviours, including tobacco smoking, poor nutrit...
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There are many reasons for a tingling feeling in the nose. It is sometimes the effect of illness and may be caused by allergies. There are many different ways to alleviate it, most of which can be done at home. Learn more about how to get rid of a tingle in the nose, and when to see a doctor for treatment, here.
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Tropical peat swamp forests (PSF) are characterized by high quantities of carbon (C) stored as organic soil deposits due to waterlogged conditions which slows down decomposition. Globally, Peru has one of the largest expanse of tropical peatlands, located primarily within the Pastaza-Marañón river basin in the Northwestern Peru. Peatland forests in Peru are dominated by a palm species—Mauritia flexuosa, and M. flexuosa-dominated forests cover ~ 80% of total peatland area and store ~ 2.3 Pg C. However, hydrologic alterations, land cover change, and anthropogenic disturbances could lead to PSF's degradation and loss of valuable ecosystem services. Therefore, evaluation of degradation impacts on PSF's structure, biomass, and overall C stocks could provide an estimate of potential C losses into the atmosphere as greenhouse gases (GHG) emissions. This study was carried out in three regions within Pastaza-Marañón river basin to quantify PSF's floristic composition and degradation status and total ecosystem C stocks. There was a tremendous range in C stocks (Mg C ha−1) in various ecosystem pools—vegetation (45.6–122.5), down woody debris (2.1–23.1), litter (2.3–7.8), and soil (top 1 m; 109–594). Mean ecosystem C stocks accounting for the top 1 m soil were 400, 570, and 330 Mg C ha−1 in Itaya, Tigre, and Samiria river basins, respectively. Considering the entire soil depth, mean ecosystem C stocks were 670, 1160, and 330 Mg C ha−1 in Itaya, Tigre, and Samiria river basins, respectively. Floristic composition and calcium to Magnesium (Ca/Mg) ratio of soil profile offered evidence of a site undergoing vegetational succession and transitioning from minerotrophic to ombrotrophic system. Degradation ranged from low to high levels of disturbance with no significant difference between regions. Increased degradation tended to decrease vegetation and forest floor C stocks and was significantly correlated to reduced M. flexuosa biomass C stocks. Long-term studies are needed to understand the linkages between M. flexuosa harvest and palm swamp forest C stocks; however, river dynamics are important natural drivers influencing forest succession and transition in this landscape.
MONDAY, April 30, 2018 -- Use of hearing aids (HAs) is associated with beneficial health outcomes, including reduced probability of emergency department visits and hospitalizations and reduced number of nights in the hospital, according to a study...
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MONDAY, April 30, 2018 -- Simultaneous liver-kidney transplant recipients' peripheral blood cells have unique phenotypic and functional characteristics that are associated with donor-specific hypo-alloresponsiveness, according to a study published...
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MONDAY, April 30, 2018 -- Adopting a healthy lifestyle, with five low-risk lifestyle factors is associated with increased life expectancy, according to a study published online April 30 in Circulation. Yanping Li, M.D., Ph.D., from the Harvard T.H....
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MONDAY, April 30, 2018 -- Enhancing physician education and training in nutrition is expected to improve engagement in diet counseling for outpatients with atherosclerotic cardiovascular disease (ASCVD), according to an American Heart Association...
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MONDAY, April 30, 2018 -- The prevalence of autism spectrum disorder (ASD) was estimated at 16.8 per 1,000 children aged 8 years in 2014, according to research published online April 27 in the U.S. Centers for Disease Control and Prevention's...
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MONDAY, April 30, 2018 -- Menstrual dysfunction is common in girls with recently diagnosed type 2 diabetes, and does not improve with two years of anti-hyperglycemic treatment, according to a study published online April 24 in the Journal of...
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MONDAY, April 30, 2018 -- Primary care management of obstructive sleep apnea (OSA) is as effective and more cost-effective than in-laboratory diagnosis, according to a study published online April 17 in the American Journal of Respiratory and...
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MONDAY, April 30, 2018 -- Critical congenital heart disease (CCHD) newborn screening detects a low percentage of new cases of CCHD, but it can detect other important diseases, according to a study published online April 24 in Pediatrics. Christina...
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MONDAY, April 30, 2018 -- A standardized, time-sensitive checklist can help guide the education process for parents of children newly diagnosed with cancer, according to an article published online March 28 in the Journal of Pediatric Oncology...
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MONDAY, April 30, 2018 -- A three-dimensional (3-D)-printed short-segment template prototype is feasible for management of complex mandibular fractures, according to a study published online April 26 in JAMA Facial Plastic Surgery. Parul Sinha,...
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We estimate multiple treatment effects in presence of selection-bias and response heterogeneity, using panel data. A control function was added to a fixed-effects based correlated random coefficients model. Selection model to create the control function was contrasted between multinomial logit and multinomial probit. For the multinomial logit model, parametric and semi-parametric bias correction techniques, as proposed in Lee (Econometrica 51(2):507–512, 1983), Dubin and McFadden (Econometrica 52(2):345–362, 1984) and Dahl (Econometrica 70(6):2367–2420, 2002) respectively, were implemented. We find that controlling time-varying endogeneity, allowing response heterogeneity, the type of bias correction method and the choice of the selection model, each had significant impact on the estimated treatment effects. Using the case of biologic DMARDs, we show that in the presence of heterogeneity and multiple treatments, the specification of the latent index model should be carefully chosen along with selection bias correction techniques appropriate to the choice of the latent index model. These issues have an important impact on policy. Under one set of assumptions, we may accept a formulary expansion policy on biologic DMARDs to be cost-neutral, while rejecting the same policy as not cost-saving under another set of assumptions.
Distal radial fractures are one of the most common orthopaedic cases that present to the A&E department. Surgical intervention is warranted in displaced intraarticular fractures and fractures with more than the recommended angulation or shortening, and is most commonly treated with volarly placed fixed angle locking plates. The aim of this study is to determine and compare the efficacy of two different plates for surgical treatment of distal radius fractures. The VRP 2.0 is a new plate produced by the Austofix company and this system will be compared against the VA-LP (Variable angle-locking plate) produced by Depuy-Synthes which has been used as the standard treatment device.
Patients between the ages of 18 and 80 presenting to the Royal Adelaide Hospital with isolated closed distal radial fractures will be invited to participate in this study. A total of 200 patients are required to provide 90% statistical power at a 5% alpha level to detect a difference of 11.5 points on the PRWE (Patient rated Wrist evaluation) score. The primary outcome measure will be the PRWE score while the secondary outcome measures will include the DASH score, EQ5D score, clinical range of movements, grip strength as well as patient perceived return of function at the wrist and time to resumption to work. These will be measured at 6 weeks, 3 months and 12 months. Radiographic indices including the radial tilt, length, volar inclination and plate prominence will also be measured. Complications will be recorded up to 12 months. Post hoc comparisons will be done using paired t tests. An intention to treat and a per protocol analysis will be done to compare the 2 groups.
Distal radial fractures are increasingly being treated by internal fixation using volar locking plates. However, there is no prospective study to date comparing one plate against another in terms of outcome and complications. This study could provide more information about the best way to treat these injuries surgically.
The trial is registered with the Australia New Zealand Clinical Trials Registry (ANZCTR). Trial registration date-17/11/2016. Trial registration number-ACTRN12616001590459.
